Selected Publications

Disease

• * T. Dugladze, I. Vida, A.B. Tort, A. Gross, J. Otahal, U. Heinemann, N. Kopell, and T. Gloveli. Impaired hippocampal rhythmogenesis in a mouse model of mesial temporal lobe epilepsy. Proc. Natl. Acad. Sci. U. S. A., 2007;104(44):17530-5.
• * D. Vierling-Claassen, P. Seikmeier, S. Stufflebeam, and N. Kopell. Modeling GABA alterations in schizophrenia: A link between impaired inhibition and altered gamma and beta range auditory entrainment. J. Neurophysiol., 2008;99(5):2656-71.
•    D. Vierling-Claasen and N. Kopell. The dynamics of a periodically forced cortical microcircuit, with an application to schizophrenia. SIAM J. Appl. Dyn. Syst., URL: http://link.aip.org/link/?SJA/8/710, DOI: 10.1137/080738052, June 2009.
• * M. McCarthy, C. Moore-Kochlacs, X. Gu, E.S. Boyden, X. Han, and N. Kopell. Striatal origin of the pathologic beta oscillations in Parkinson's disease. Proc. Nat. Acad. Sci. U. S. A., 2011;108(28):11620-5.
•    T. Dugladze, N. Maziashvili, C. Börgers, S. Gurgenidze, U. Häussler, A. Winkelmann, C.A. Haas, J.C. Meier, I. Vida, N. Kopell, and T. Gloveli. GABAB autoreceptor-mediated cell-type specific reduction of inhibition in epileptic mice. Proc. Nat. Acad. Sci., 2013, Sep 10; 110(37):15073-8.
•    S. Santaniello, M. McCarthy, E. Montgomery Jr, J. Gale, N. Kopell, and S. Sarma. Therapeutic mechanisms of high-frequency stimulation in Parkinson's disease and neural restoration via loop-based reinforcement. Proc. Natl. Acad. Sci. U. S. A., 2015 Feb 10;112(6):E586-95. doi: 10.1073/pnas.1406549111. Epub 2015 Jan 26.
• * K. Kondabolu, E. Roberts, M. Bucklin, M. McCarthy, N. Kopell, and X. Han. Striatal cholinergic interneurons generate beta and gamma oscillations in the corticostriatal circuit and produce motor deficits. Proc. Natl. Acad. Sci. U. S. A., 2016 May 31;113(22):E3159-68. doi: 10.1073/pnas.1605658113. Epub 2016 May 16.
• * B. Pittman-Polletta, A. Quach, A. Mohammed, M. Romano, K. Kondabolu, N. Kopell, X. Han, and M. McCarthy. Striatal cholinergic receptor activation causes a rapid, selective, & state-dependent rise in corticostriatal beta activity. Eur. J. Neurosci., http://dx.doi.org/10.1111/ejn.13906, 2018.
• * E. Adam, E. Brown, N. Kopell, and M. McCarthy. Deep brain stimulation in the subthalamic nucleus for Parkinson’s disease can restore dynamics of striatal networks. Proc. Nat. Acad. Sci., May 10;119(19):e2120808119. doi: 10.1073/pnas.2120808119. Epub 2022 May 2.
• * M. Murdock, C.Y. Yang, N. Sun, P.C. Pao, C. Blanco-Duque, M. Kahn, N. Lavoie, M. Victor, F.M. Islam, F. Galiana, N. Leary, S. Wang, A. Bubnys, E. Ma, L. Akay, T. Kim, M. Sneve, Y. Qian, C. Lai, M. McCarthy, N. Kopell, M. Kellis, K. Piatkevich, E. Boyden, and L.H. Tsai. Multisensory stimulation promotes glymphatic clearance of amyloid. Nature, 2024 Mar;627(8002):149-156. doi: 10.1038/s41586-024-07132-6. Epub 2024 Feb 28.