Erin Munro

NSF Mathematical Sciences Postdoctoral Fellow

Mathematics Department

Boston University, Boston MA

Phone: 617-353-1461

Email: ecmun at math.bu.edu

 

Curriculum Vitae

Research Statement

Teaching Statement

Publication List





Research

I study networks of axons electrically coupled by gap junctions, or the axonal plexus (as illustrated above). There is evidence for an axonal plexus among pyramidal cells in the neocortex, hippocampus, and cerebellum. These systems are an example of an excitable system connected together in a random graph. They are related to models of the heart, pancreas, and other electrically coupled excitable media that can exhibit heterogeneity. My research on these systems involves: computational neuroscience, dynamical systems, graph theory, cellular automata, and scientific programming. My specific goals are to describe the dynamics of these networks in the normal brain and in epilepsy.

 

In my dissertation, I showed that the axonal plexus exhibits 3 different behaviors, depending on the somatic voltage and gap junction conductance:

Re-entrant activity and externally-driven oscillations are two different kinds of very fast oscillation (> 80 Hz), seen when cells are depolarized in the brain. I have movies depicting each behavior. For more information, see my poster, talk, or paper on The Axonal Plexus. All code is available on ModelDB. There is also an article about my doctoral research in the Alma Matters Plus Archives for the Tufts University GSAS.

 

As a postodoc at BU, I created a realistic model of the neocortical axonal plexus. This model shows that:

For more information, see my poster presented at CNS*2010 or talk.

 

 

Publications

Erin Munro and Nancy Kopell. Neocortical pyramidal cells can send signals to post-synaptic cells without firing: a model of the axonal plexus. Submitted.

Erin Munro and Christoph Börgers. Mechanisms of very fast oscillations in networks of axons coupled by gap junctions. J. Comput. Neurosci. 2010, 28(3):539-55

Erin Munro. The axonal plexus: a description of the behavior of a network of neurons connected by gap junctions. Ph.D. dissertation, Mathematics, Tufts University, 2008

Erin Munro and Christoph Börgers. The axonal plexus: a description of the behavior of a network of neurons connected by gap junctions. BMC Neuroscience 2007, 8 (Suppl 2):P47

 

Posters

A Model of Very Fast Oscillations in a Realistic Cortical Axonal Plexus

The Axonal Plexus: A description of the behavior of a network of axons connected by gap junctions

Electrically Coupled Integrate-and-Fire Neurons

 

Talks

A realistic neocortical axonal plexus model has implications for neocortical processing and temporal lobe epilepsy

The Axonal Plexus: A description of the behavior of a network of axons connected by gap junctions

 

Movies

 

Other links of interest