The Dynamical Systems seminar is held on Monday afternoons at
4:00 PM in CCDS 548 . There will be a brief tea in CCDS 548 at 3:45PM.
September 14th Jie Zang
(Brown University)
Title: TBA
Abstract: TBA
September 21st Greg Handy (U of Minnesota - Twin Cities) - TALK CANCELLED DUE TO BU SNOW DAY, we plan to reschedule later in the semester.
Title: Glial ensheathment of inhibitory synapses drives hyperactivity and increases correlations
Abstract: Recent evidence shows that glial cells actively modulate neuronal dynamics. A recent study notably found that during and after anesthesia, microglia ensheath inhibitory synapses, disrupting neurotransmitter flow. In this talk, I will develop computational models that explore how this ensheathment affects neuronal dynamics. Extending a microscale synaptic cleft model, I show that ensheathment accelerates synaptic transmission but reduces its strength. I will then integrate this microscale model into a large network of exponential integrate-and-fire neurons, which introduces heterogeneous synaptic parameters determined by glial proximity, and extend linear response theory to analyze firing rates and noise correlations. I will show that this model reproduces the experimental finding that increased glial ensheathment of inhibitory synapses leads to hyperactivity and predicts significant increases in power spectrum magnitude across task-relevant frequencies, suggesting glial-driven synaptic plasticity is an underappreciated mechanism for modulating cortical dynamics.